NASS 2024 RECAP
Advancing Spine Innovation:
Research, Technology, and Venture Capital Insights from NASS 2024
Kai-Uwe Lewandrowski, MD
Center for Advanced Spine Care of Southern Arizona Tucson, AZ
Introduction
The 39th Annual Meeting of the North American Spine Society (NASS), held from September 25-28, 2024, in Chicago, brought together leading professionals to discuss groundbreaking advancements in research and technology applications in spine care. This event showcased the latest developments in spinal fusion, surgical training, artificial intelligence (AI), personalized implants, and funding innovation. It provided a rich platform for exploring the intersection of innovation and investment in spine care. A highlight of the event was the session on venture capital (VC) and its critical role in driving transformative advancements. This session featured insights from six distinguished speakers, each offering a unique perspective on the evolving financial landscape of spine technology. Their collective expertise underscored the complexities of funding innovation in a highly competitive and commoditized market.
Speakers and Their Contributions
Marc Viscogliosi
Viscogliosi Brothers, LLC
Marc Viscogliosi opened the session with a comprehensive analysis of the VC landscape in spine care. He discussed how commoditization and redundancy in product offerings have pressured companies to innovate beyond incremental improvements. His insights emphasized the importance of identifying transformative technologies that offer a clear clinical and financial advantage.
Zorica Buser, PhD, MBA
Director of Research and Regenerative Medicine, NY Orthopedics PC; Research Assistant Professor, NYU Grossman School of Medicine
Dr. Buser highlighted the role of regenerative medicine in spine care and the need for long-term investment to bridge the gap between surgical success and patient outcomes. She stressed the value of biologics and their potential to revolutionize the field if supported by robust clinical data and strategic funding.
Lisa Ferrara, PhD
Managing Member, Hypoid Ventures, LLC
Dr. Ferrara discussed the advancements in patient-specific implants and the role of VC in accelerating the adoption of 3D-printed technologies. She showcased case studies demonstrating the clinical efficacy and patient benefits of custom implants, urging investors to recognize their long-term potential despite initial high costs.
Ali Kiapour, PhD
Department of Neurosurgery, Massachusetts General Hospital; Harvard Medical School
Dr. Kiapour’s presentation focused on the promise of AI in spine care, particularly in enhancing diagnostics and surgical planning. He explored how VC funding could drive the development and integration of AI tools, while highlighting the ethical and regulatory challenges that AI presents.
Alexander Satin, MD
Spine Surgeon and Spine Fellowship Co-Director
Dr. Satin addressed the role of virtual reality (VR) in advancing surgical education through simulation technologies. He underscored how investment in VR and high-fidelity simulators can fill critical training gaps, ultimately leading to safer and more efficient surgical practices.
Jeffrey C. Wang, MD
Professor of Orthopaedic Surgery and Neurosurgery, USC Spine Center, USC School of Medicine
Dr. Wang provided an overview of the latest trends in spinal fusion technologies, emphasizing the need for VC investment in biologically active cages and advanced instrumentation. He highlighted the growing demand for minimally invasive approaches and how financial backing can accelerate their development and adoption.
Advancements in Spinal Fusion and Enabling Technologies
Presenter: Dr. Jeffrey C. Wang
Dr. Jeffrey C. Wang provided an in-depth exploration of the latest advancements in spinal fusion, highlighting the evolving role of enabling technologies and minimally invasive surgery (MIS) in patient care. His presentation underscored the importance of balancing cutting-edge innovation with evidence-based practices and economic sustainability.
Innovations in Spinal Fusion
Spinal fusion has seen remarkable advancements, particularly with the integration of biologics and enhanced instrumentation. Dr. Wang emphasized the potential of future biologics to replace rh-BMP-2 such as oxysterol and its over 100 synthesized analogues, including Oxy133 which was found to induce significant expression of osteogenic markers Runx2, osterix (OSX), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OCN). These biologics promote bone growth and should improve fusion outcomes.
Innovative instrumentation, including biologically active cages and 3D-printed implants, offers personalized solutions tailored to patient-specific anatomy. These advancements should improve load-sharing and fusion rates while reducing surgical complications. The development of new screw designs and modular systems also enhances procedural efficiency, reflecting industry’s focus to improve both patient outcomes and surgeon experience.
Enabling Technologies and Minimally Invasive Surgery (MIS)
Technological innovations have fundamentally reshaped spinal surgery, with tools like navigation systems, robotic guidance, and neuromonitoring becoming indispensable. These enabling technologies enhance surgical precision, reduce intraoperative risks, and facilitate minimally invasive approaches.
MIS techniques offer several advantages including reduced recovery times, lower infection risks, and improved patient satisfaction. However, Dr. Wang noted that adopting these technologies is not without challenges. Surgeons often face a steep learning curve, requiring “backward learning,” as they adapt to new tools and techniques. This transition can initially result in longer operative times and higher costs; hopefully the long-term benefits justify the investment.
A standout feature of NASS 2024 was the Surgical Stadium Lab, where surgeons demonstrated these technologies. Live procedural showcases provided attendees with a detailed understanding of advanced MIS techniques and the latest enabling technologies, bridging the gap between theoretical knowledge and practical application.
Economic Considerations and Policy Implications
The integration of novel technologies in spinal surgery presents significant economic challenges. Dr. Wang highlighted the role of regulatory and reimbursement frameworks, particularly the influence of the Current Procedural Terminology (CPT) and Relative Value Scale Update Committee (RUC). These procedural metrics were designed to evaluate new surgical technologies and determine reimbursement rates, based on time required, risk, and resources required.
Table 1. Key Takeaways on Advancements in Spinal Fusion and Enabling Technologies
A critical issue discussed at NASS 2024 was the devaluation of existing procedures following the introduction of new CPT codes. This creates a complex environment where the financial viability of adopting new technologies must be weighed against their demonstrated clinical benefits. Dr. Wang emphasized the need for selective advocacy, focusing on technologies that improve patient outcomes while maintaining cost-effectiveness.
Key takeaways included the importance of evidence-based practice in driving innovation. Policymakers, health care providers, and industry stakeholders must collaborate to ensure that advancements in spinal surgery align with sustainable health care delivery models (Table 1).
Dr. Wang's presentation highlighted the dynamic interplay between technological innovation and practical application in spinal fusion. By integrating technologies and advancing MIS, the spine care community may achieve better outcomes and improved patient satisfaction. However, as these innovations are adopted, careful consideration of their economic impact and policy implications will be essential to ensure long-term sustainability and accessibility.
Bridging the Gap in Surgical Training
Presenter: Dr. Alexander Satin
The rapidly evolving landscape of spine surgery has intensified the need for advanced surgical training methods. Traditional training paradigms may not be sufficient for success in the modern clinical environment.
Challenges in Surgical Training
One of the key issues in contemporary surgical education is reduced clinical exposure due to work-hour restrictions. Many trainees complete fewer than 100 spine cases during their residency, far below the threshold required for proficiency. Additionally, cadaveric training, while effective, poses challenges related to cost, logistics, and ethical considerations.
Technological Solutions
- Virtual Reality (VR): VR simulations provide immersive, interactive environments for skill development. Dr. Satin discussed how VR enables trainees to practice complex procedures repeatedly without the need for physical resources. Studies presented at the annual meeting revealed that VR training significantly improves procedural accuracy and reduces fluoroscopy time.
- Synthetic Simulators: These models range from simple anatomical replicas to high-fidelity systems that simulate real-life surgical scenarios. Advanced simulators offer tactile feedback, allowing trainees to experience the resistance and texture of human tissues. Such simulations have proven invaluable for mastering techniques like screw placement and osteotomies.
Simulation-Based Training Outcomes & Real-World Surgical Ability
Randomized controlled trials comparing traditional and simulation-based training consistently show superior outcomes in the simulation groups. Metrics such as error rates, operative time, and expert evaluations indicate that simulation-trained surgeons are better prepared for real-world challenges.
Dr. Satin’s presentation underscored the transformative potential of simulation technologies in modern surgical education. He highlighted the challenges posed by reduced clinical exposure and traditional cadaveric training, advocating for the integration of virtual reality (VR) and high-fidelity synthetic simulators. These tools offer risk-free, cost-effective training environments that enhance technical skills and procedural confidence. By bridging critical gaps in surgical training, simulation technologies not only improve real-world performance but also set new standards for competence and safety in spine surgery education (Table 2).
Table 2. Key Takeaways on Bridging the Gap in Surgical Training
AI in Spine Surgery: Promise and Perils
Presenter: Dr. Ali Kiapour
Artificial Intelligence (AI) is reshaping health care, and spine care is no exception. Dr. Kiapour reviewed how AI is being integrated into diagnostics, surgical planning, and operational workflows.
Enhancing Spine Care with AI
- Improved Diagnostic Accuracy: AI-driven tools, such as convolutional neural networks (CNNs), enhance the accuracy of diagnosing spinal conditions like stenosis and fractures. These tools analyze imaging data to detect abnormalities with high precision. Advanced systems like SpineNet automate vertebral body localization and grading of spinal degeneration, significantly improving the speed and accuracy of diagnoses. Predictive algorithms also help forecast postsurgical complications, aiding in effective risk stratification.
- Personalized Care and Surgical Planning: Machine learning models allow for highly personalized treatment plans by analyzing patient-specific data, including imaging results and demographic information. These models predict the risk for suboptimal outcomes, such as the likelihood of chronic pain or the need for revision surgeries, enabling surgeons to tailor postoperative care. Additionally, AI-powered robotic systems enhance surgical precision, minimizing intraoperative complications and optimizing recovery trajectories.
- Operational Efficiency: AI contributes to streamlined workflows through automation. For instance, AI-powered scribe tools reduce documentation burdens, freeing up clinicians to focus more on patient care. Triage bots and automated scheduling systems improve clinic operations by managing patient flow, reducing no-show rates, and optimizing resource allocation.
Challenges in AI Integration
While promising, the integration of AI into spine care is fraught with challenges, specifically:
- Algorithmic Bias: AI models often inherit biases from the datasets they are trained on, which can lead to disparities in care. Minority populations are frequently underrepresented in medical datasets, resulting in less accurate predictions and potentially inappropriate treatment recommendations for these groups.
- Over-Reliance and Skill Degradation: As clinicians become increasingly dependent on AI tools, there is a risk of skill degradation. New medical professionals may lack essential diagnostic and decision-making experience if they overly rely on AI, potentially compromising the quality of care in scenarios where AI is unavailable or ineffective.
Ethical and Legal Considerations
The ethical implications of AI in health care cannot be overlooked. Issues such as data privacy, the opacity of AI decision-making (“black box” problem), and legal accountability for AI-driven errors pose significant challenges. The use of AI in health care raises complex ethical and legal concerns.
- Data Privacy and Security: AI systems rely heavily on patient data, raising significant privacy and security concerns. Unauthorized data access or breaches could lead to identity theft or the misuse of sensitive medical information, undermining patient trust.
- Lack of Explainability: Many AI models function as “black boxes,” providing little insight into how they arrive at their conclusions. This lack of transparency can create trust issues among clinicians and patients.
- Legal Accountability: Determining liability in cases of AI-assisted medical errors is a challenging task. Current legal frameworks often fall short in addressing scenarios where AI contributes to decision-making, raising questions about who is ultimately responsible—the clinician, the AI developer, or the health care institution.
AI is revolutionizing spine care, offering significant advancements in diagnostics, personalized treatment, and operational efficiency. However, its integration into clinical practice also presents notable challenges and ethical dilemmas. Dr. Ali Kiapour’s session comprehensively reviewed and provided a comprehensive overview of the promise and pitfalls of AI in spine surgery, highlighting both its transformative potential and the hurdles that must be addressed (Figure 1).
Figure 1. Dynamic state diagram illustrating the integration process of AI in spine care. The diagram begins with the Evaluate Potential AI state, where potential AI solutions and their benefits are assessed. Upon identifying promising applications, the process transitions to the Implement AI state, where AI systems are integrated into clinical practice. Once implemented, the system enters the Monitor Outcomes state to assess effectiveness and performance. Feedback from this monitoring informs the Adjust AI Models state, where refinements and adjustments are made based on data analysis.
Case Studies and Applications
Dr. Kiapour presented several case studies that illustrate the practical applications of AI in spine surgery:
- Predicting Pedicle Screw Pullout Strength: A Random Forest model using bone density and insertion angle data demonstrated high accuracy in predicting pedicle screw pullout strength. This application supports surgical planning, particularly in osteoporotic patients.
- Scoliosis Curve Prediction: An AI model utilizing trunk surface topography provided a noninvasive alternative to frequent X-rays, achieving a 72.2% accuracy rate in predicting scoliosis classification. This innovation reduces patient exposure to radiation while maintaining diagnostic reliability.
AI has the potential to enhance spine care by improving diagnostics, enabling personalized treatment, and improving operational efficiency. However, its integration into clinical practice must be approached with caution to address inherent biases, avoid overreliance, and navigate complex ethical and legal challenges. As Dr. Kiapour emphasized, the future of AI in spine surgery will depend on fostering collaboration between clinicians and AI developers to create transparent, equitable, and patient-centered solutions.
Custom 3D-Printed Implants: Revolutionizing Personalized Spine Care
Presenter: Dr. Lisa Ferrara
Dr. Ferrara’s presentation underscored the clinical and biomechanical advantages of personalized implants. Custom 3D printed patient-matched implants (PMIs) are emerging in spine and orthopedic surgeries. These implants are tailored to the patient’s unique anatomy, offering solutions where conventional devices fall short due to anatomical complexities. Dr. Ferrara's presentation highlighted the technological advancements, benefits, challenges, and potential of these implants in improving patient care.
Clinical Applications and Benefits of Patient-Matched Implants
Custom PMIs are tailored to the patient’s anatomy, ensuring optimal fit and load distribution. They reduce intraoperative adjustments, shorten operating times, and improve aesthetic and functional outcomes. Dr. Ferrara shared compelling case studies where PMIs successfully addressed complex spinal deformities and tumor resections.
The Workflow of Patient-Specific Implant Fabrication
The process begins with detailed imaging (CT or MRI) to capture the patient’s anatomy. Surgeons and engineers collaborate to design an implant tailored to the patient’s specific needs. Advanced computational modeling and finite element analysis (FEA) validate the implant’s biomechanical performance. Once approved, the implant is manufactured using 3D printing technology and is ready for surgical implantation (Figure 2).
Figure 2. Flowchart illustrating the advantages and workflow of patient-specific implant fabrication. Advantages include Improved Fit and Functionality, Reduced Operating Room (OR) Time, Enhanced Patient Satisfaction, and Optimized Load-Sharing. The workflow covers Detailed Imaging (CT/MRI), Collaboration in Design, Computational Modeling & FEA, Approval & Manufacturing (3D printing), and Surgical Implantation.
Case Studies Demonstrating PMI Success
Dr. Ferrara presented several clinical cases showcasing the effectiveness of PMIs:
- Left Hemipelvis Implant: For a patient with recurrent chondrosarcoma, a custom hemipelvis implant provided a perfect fit and improved load-sharing.
- Multilevel Spine Fixation Construct: In a chordoma case spanning four vertebrae, a patient-specific spine implant delivered superior biomechanical stability.
- Sternum Implant: After a sternectomy due to mediastinitis, a custom sternum implant restored structural integrity and functionality.
Challenges, Regulatory Considerations, and Future Directions
The high cost and regulatory hurdles of PMIs remain barriers to widespread adoption. However, advancements in AI and bioprinting are expected to drive the next wave of innovation, enabling the integration of living tissues into implants for enhanced biological performance. Despite their promise, PMIs face significant challenges:
- Testing and Validation: The complexity of PMI design makes comprehensive testing difficult. Ensuring biomechanical and clinical safety remains a top priority.
- Regulatory Hurdles: Gaining approval from regulatory bodies requires robust evidence of efficacy and safety.
- Cost and Accessibility: Although 3D printing reduces lead times, the technology remains expensive and may limit widespread adoption.
The future of PMIs lies in integrating advanced technologies like artificial intelligence (AI) and bioprinting. AI-driven design can optimize implant geometry, improve surgical planning, and personalize treatment further. Bioprinting, which involves printing tissues and organs using patient-derived cells, represents the next frontier in regenerative medicine. This could enable the creation of implants that not only match the patient’s anatomy but also promote biological integration and tissue regeneration.
Venture Capital in Spine Innovation: Navigating Opportunities and Challenges
Presenter: Marc Viscogliosi
Venture capital (VC) plays a crucial role in fostering innovation within the spine care industry. As traditional funding mechanisms fail to keep up with rapid technological advancements, VC provide the financial backing needed to bring new technologies to market. Marc Viscogliosi’s session offered an in-depth examination of the opportunities and challenges involved in funding spine innovations.
The Current Role of VC Investment in Spine Care
The spine care market has long been characterized by intense competition and commoditization, which have profound implications for innovation and investment. Commoditization occurs when products within a market, such as spinal implants or surgical tools, become so similar that differentiation is difficult. This has led to a “race to the bottom” in pricing, with companies vying to undercut one another to maintain market share.
Key Issues in the Spine Market
- Product Redundancy: Many companies develop overlapping product portfolios, offering devices that serve identical functions with minimal differentiation. This redundancy saturates the market and diminishes the perceived value of each product.
- Price Erosion: High competition leads to aggressive pricing strategies, which erode profit margins and disincentivize long-term investment in research and development (R&D).
- Underinvestment in Breakthroughs: With diminishing returns on incremental improvements, companies are hesitant to allocate resources to high-risk, high-reward innovations, such as disruptive biologics or robotics.
Impact of Commoditization on VC Investment
Commoditization presents both challenges and opportunities for venture capitalists. On one hand, the high level of competition and price pressure can deter investment in markets perceived as saturated. On the other hand, VCs have the potential to fund companies that break free from this cycle by focusing on transformative technologies.
Challenges for VC Firms
- Overlapping Portfolios: A major concern for VCs is investing in companies with overlapping product lines that fail to distinguish themselves in the market. This results in cannibalization of market share within the portfolio and limits the potential for robust returns.
- Reduced Return on Investment (ROI): In commoditized markets, even successful products struggle to command premium pricing, making it harder for VCs to achieve their desired ROI.
- Dilution of Competitive Advantage: As competitors rapidly adopt similar innovations, any initial market advantage can be quickly eroded, reducing the window of opportunity for high-margin sales.
However, there are strategies that VCs can employ to mitigate these risks and capitalize on market opportunities (Table 3).
Table 3. Venture Capital Strategies in the Spine Surgery Market
The Shift Toward Transformative Technologies
To counteract the negative effects of commoditization, VCs are increasingly looking to fund platform technologies that represent paradigm shifts rather than incremental improvements. Examples include:
- Interventional Spine Technologies: Minimally invasive procedures, such as robotic-guided interventions and next-generation biologics, are gaining traction due to their potential for better patient outcomes and reduced recovery times.
- Smart Implants and Wearable Tech: Devices that provide real-time feedback, such as kinematic data or infection monitoring, offer a new value proposition, extending beyond traditional mechanical functions.
- Advanced Surgical Planning Tools: AI-driven solutions, such as predictive analytics for surgical outcomes and automated preoperative planning, are becoming essential tools in precision spine care.
Success Stories: Bridging the Innovation Gap
Several companies have successfully navigated the challenges of commoditization to bring innovative solutions to market, providing valuable lessons for both entrepreneurs and VCs:
- Canary Medical's Smart Spinal Fusion Implant: This device collects kinematic data post-surgery, allowing for remote monitoring of fusion progression. Such innovations not only improve clinical outcomes but also differentiate the product in a crowded market.
- Orthobond's Antibacterial Coating Technology: With FDA approval, Orthobond’s technology adds significant value by reducing the risk of infection, a critical concern in spine surgery.
These companies illustrate the potential for VCs to realize significant returns by backing technologies that address unmet clinical needs and provide clear differentiation.
Future Directions for VC Investment
Mr. Viscogliosi emphasized that the future of VC investment in spine care lies in identifying and supporting companies that align with evolving market demands. Key factors for successful investment include (Table 4):
- Market Timing: Ensuring that the innovation is introduced at the right time to capitalize on market readiness and avoid premature obsolescence.
- Strategic Differentiation: Prioritizing investments in companies with proprietary technologies or strong intellectual property (IP) that provide a competitive moat.
- Portfolio Synergy: VCs should aim to build portfolios with complementary rather than competing technologies, maximizing the collective value of their investments.
Table 4. Key Factors for Successful Investment
The Role of VCs in Shaping the Future of Spine Care
Venture capital is poised to play a pivotal role in driving the next wave of innovation in spine care. By navigating the challenges of commoditization and focusing on transformative technologies, VCs can unlock significant value for both their portfolios and the broader health care system. As Mr. Viscogliosi noted, strategic partnerships between innovators and investors are critical to sustaining growth and advancing the field of spine surgery. The “golden age of innovation” in spine care is here, and VCs have a unique opportunity to shape its trajectory.
Conclusion
The NASS 2024 Annual Meeting highlighted the dynamic interplay between innovation, clinical practice, and economic considerations in spine care. From advanced biologics and AI to personalized implants and simulation training, the future of spine surgery is being shaped by technology. However, success will require a balanced approach, integrating evidence-based practices with strategic investments to ensure sustainable and patient-centered care.